Notify your doctor if you are pregnant or Imagine you may be pregnant. During pregnancy, this product or service isn't proposed. It could hurt an unborn infant. Talk to your doctor regarding the hazards and advantages of this medication. See also Warning segment.
Promethazine administered to the Expecting lady inside two weeks of shipping might inhibit platelet aggregation while in the newborn.
Epinephrine – Due to the probable for promethazine to reverse epinephrine's vasopressor impact, epinephrine should NOT be made use of to deal with hypotension linked to promethazine overdose.
Promethazine and codeine mixture is utilised To ease cough, runny or stuffy nose, sneezing, or other symptoms due to allergic reactions or the frequent chilly.
This medication can dry up and thicken mucus in the lungs, which makes it harder to breathe and clear your lungs. To help reduce this effect, drink a lot of fluids Until normally directed by your health practitioner.
Postmarketing scenarios of respiratory melancholy, including fatalities, happen to be claimed with use of promethazine hydrochloride in pediatric individuals fewer than two a long time of age. A wide range of weight-primarily based doses of promethazine hydrochloride have resulted in respiratory depression in these sufferers.
Usually do not choose this medication for a number of times right before allergy testing due to the fact test results could be afflicted.
Promethazine Carcinogenicity experiments had been conducted with promethazine hydrochloride. Two-calendar year research in F344/N rats and B6C3F1 mice were being performed to evaluate the carcinogenic potential of promethazine hydrochloride. No proof of tumorigenicity was observed in male and female rats at promethazine hydrochloride oral doses around 33 mg/kg/day for 5 days/7 days (about comparable to ten situations the MRHD with a mg/m2 basis).
Narcotic analgesics, such as codeine, exert their Key consequences on the central anxious system and gastrointestinal tract. The analgesic outcomes of codeine are as a consequence of its central action; however, the precise web pages of motion have not been decided, plus the mechanisms included appear to be fairly sophisticated.
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The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate, necessitating careful thing to consider of the effects about the mum or dad drug, codeine, as well as the Lively metabolite, morphine.
Treatment of Overdose Treatment method of overdosage Promethazine codeine syrup is driven by the overall medical presentation, and consists of discontinuation of Promethazine HCl and Codeine Phosphate Oral Answer along with institution of correct therapy. Give primary consideration to the reestablishment of adequate respiratory Trade by provision of the patent and protected airway and the establishment of assisted or managed air flow.
1)]. All people treated with opioids involve thorough checking for indications of abuse and dependancy, since usage of opioid analgesic and antitussive solutions carries the chance of habit even under acceptable clinical use.
Offering or freely giving Promethazine Hydrochloride and Codeine Phosphate Oral Solution may possibly harm Some others, which is in opposition to the law. Notify your healthcare provider In case you have ever abused or been dependent on Alcoholic beverages, prescription medicines or Road drugs.